Abstract
2-Arylbenzoxazoles, benzothiazoles and benzimidazoles were identified as new classes of potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-beta (LPAAT-beta). Effects of selected inhibitors on proliferation of tumor cells in vitro were investigated.
MeSH terms
-
Acyltransferases / antagonists & inhibitors*
-
Acyltransferases / metabolism
-
Benzimidazoles / chemistry*
-
Benzimidazoles / pharmacology
-
Benzothiazoles
-
Benzoxazoles / chemistry*
-
Benzoxazoles / pharmacology
-
Cell Line, Tumor
-
Enzyme Inhibitors / chemistry*
-
Enzyme Inhibitors / pharmacology
-
Humans
-
Structure-Activity Relationship
-
Thiazoles / chemistry*
-
Thiazoles / pharmacology
Substances
-
Benzimidazoles
-
Benzothiazoles
-
Benzoxazoles
-
Enzyme Inhibitors
-
Thiazoles
-
Acyltransferases
-
2-acylglycerophosphate acyltransferase
-
benzothiazole